When suspicions turn to real evidence

Turn to TCRs when CARs fail

The past few years have brought exciting progress in the development of novel forms of immunotherapy of cancer. While antibody blockade of negative pathways that inhibit T cell function, such as CTLA-4 and PD1, has resulted in clinical benefits for patients who have failed conventional therapy options, this strategy lacks cancer specificity as it also activates T cells with selfreactive potenti...

Bacterial Pathogenesis: When a turn off is a turn on

Pathogenic bacteria express distinct sets of genes at different stages in their life cycles; inappropriate expression of normally repressed genes during host colonization can interfere with bacterial survival.

Surface-to-Surface Morphology: when your Representations turn into Constraints

Traditional morphology, that cranks out ‘underlying representations’ destined for phonology, has a serial character that makes it an odd bedfellow to parallel OT. The problem becomes all the more acute once one recognizes the need for ‘surface-to-surface’ faithfulness constraints (Benua 1997, Burzio 1994a, Kenstowicz 1996, Steriade 1996), given the ability of the latter to do -in parallelsome o...

Capacity Allocation Using Past Sales: When to Turn-and-Earn

Consider a supplier selling to multiple retailers. Demand varies across periods, but the supplier’s capacity and wholesale price are fixed. If demand is high, the retailers’ needs exceed capacity, and the supplier must implement an allocation mechanism to dole out production. We examine how the choice of mechanism impacts retailer actions and supply chain performance. In particular, we analyze ...

To the Framingham data, turn, turn, turn.